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KMID : 0191119900050010039
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Journal of Korean Medical Science
1990 Volume.5 No. 1 p.39 ~ p.45
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Kinetics of isoniazid transfer into cerebrospinal fluid in patients with tuberculous meningitis
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신상구:Shin Sang-Goo
노재규:Roh Jae-Kyu/이남수:Lee Nam-Soo/신재국:Shin Jae-Gook/장인진:Jang In-Jin/박찬웅:Park Chan-Woong/명호진:Myung Ho-Jin
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Abstract
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For the pharmacokinetic analysis of isoniazid transfer into CSF, steady-state isoniazid
concentrations of plasma and CSF were measured in eleven tuberculous meningitis patients confirmed with findings of CSF and neuroimazing. Peak plasma levels (4.17-21.5 micrograms/mL) were achieved at 0.25 to 3 hours after multiple isoniazid dose (600 mg/day). Terminal half-life, total clearance (CI/F) and volume of distribution (Vd/F) were 1.42 +/- 0.41 hr, 0.47 +/- 0.22 L/kg/hr and 0.93 +/- 0.48 L/kg, respectively. Isoniazid concentrations in CSF collected intermittently were highest at 3 hr (Mean, 4.18 micrograms/mL) and were 0.54 +/- 0.21 micrograms/mL at 12 hrs after the last dose of isoniazid 10 mg/kg/day. CSF/plasma partitioning of isoniazid and equilibration rate were estimated using modified pharmacokinetic/pharmacodynamic model. Disposition rate constant from CSF to plasma and CSF/plasma partitioning ratio of isoniazid were estimated to be 0.39 h-1 and 1.17, respectively.
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KEYWORD
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